Thieme E-Journals – Clinical Paediatrics

publication history

Publication Date:24 July 2008 (online)

Summary of the

Background: The therapy of choice for macrocystic lymphangiomas is complete resection. However, due to the growth pattern of this congenital malformation and the main localization in the head and neck area, resection is often only incompletely possible. An alternative is sclerosing with Picibanil. Experience with the use of Picibanil in infants has so far only been available in the form of case reports.

Patient/Method: From 2002 to 2006, retrospectively the data of 8 children, aged from 2 weeks to 12 months, who were treated with Picibanil for macrocystic or mixed cystic lymphangioma as part of a curative trial, were processed. The follow-up period was 3 months to 3 years.

Results: Postoperatively all patients showed a local swelling, in 4 cases accompanied by redness and fever. A tumor regress of > 50% occurred in 7 of the 8 patients.

Conclusion: The injection of Picibanil also offers a safe alternative or supplement to surgical resection in infants, especially if complete removal can only be achieved by injuring important structures. However, multi-centric prospective studies are required to demonstrate superiority over primary surgical resection.


Background: The therapeutic gold standard of cystic hygroma is its complete resection. Because of its growth pattern and its main location in the head and neck region complete resection is not always possible. An alternative is the local injection of Picibanil, but only few cases have been published about its use in infants.

Patients/Method: We retrospectively analyzed the data of 8 infants (age: 2 weeks – 12months) who got Picibanil therapy because of cystic hygroma in the time period 2002 until 2006. Follow up ranged from 3 months up to 3 years.

Results: During the postoperative period all patients had local swelling, in 4 cases accompanied with local inflammation and fever. Tumorreduction of > 50% was obtained in 7 of 8 patients.

Conclusions: Local injection of Picibanil in infants with cystic hygroma seems to be a safe alternative to surgical therapy, especially when complete tumorresection means damage of important neighbouring structures. Prospective trials are necessary to confirm the better outcome after therapy with Picibanil compare to primary surgery.

key words

Picibanil – Lymphangioma – OK 432 – Infants – Childhood

Key words

Picibanil – lymphangioma – OK 432 – newborns – infants


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correspondence address

Dr. K. Reinshagen

Pediatric Surgery, University Hospital Mannheim

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