Amfepramone – effect, application & risks


amfepramone is an indirect alpha-sympathomimetic and is used in Germany as an appetite suppressant. Due to a not insignificant potential for abuse the active substance is only briefly prescribed for the supportive treatment of obesity in urgent cases.

Table of Contents

What is amfepramone??

Amfepramone is also referred to as 2-diethylamino-1-phenylpropan-1-one, 2-diethylaminopropiophenone, amfepramone or diethylpropion. It belongs to the group of phenylethylamine derivatives. These are chemical compounds derived from phenylethylamine. Phenylethylamines are widely used in nature (for example, the neurotransmitter dopamine or the amino acid-like substance tyramine) or are manufactured artificially (for example, certain amphetamines).

In the field of phenylethylamines amfepramone joins the subgroup of cathinones. The eponymous name for the cathinone is the compound cathinone, which belongs to the amphetamines and has a stimulating effect. Amfepramone also acts as a stimulant and stimulates the sympathetic, a part of the autonomic (vegetative) nervous system.

It is assigned to the drug group of alpha-sympathomimetics. Commercially, it is available as a prescription drug under the trade names Regenon and Tenuate. Amfepramon falls under the Narcotics Act in Germany, but is marketable and may be prescribed by the doctor.

Pharmacological action

Amfepramone acts as an indirect alpha-sympathomimetic. While direct alpha-sympathomimetic drugs mimic the action of adrenaline by binding to the same receptors, indirect alpha-sympathomimetics lead to a release of dopamine and norepinephrine, which then stimulate the sympathetic nervous system. In this way, amfepramone stimulates the cardiovascular system and certain organs, but also acts central nervous by crossing the blood-brain barrier to brain activity.

The active ingredient thus briefly increases the physical and mental performance and increases the attention. The circulation in the lungs, blood pressure and heart rate increase. In addition, amfepramone suppresses the sensation of fatigue, inhibits thirst, and causes a reduction in food intake and appetite (via a point of attack located in the hypothalamus).

Due to the manifold effects on the whole organism, a prescription of amfepramone will be very carefully weighed by the doctor to avoid unwanted effects.

Medical application & use

Alpha-sympathomimetics are used as anorectics (appetite suppressants). Amfepramone is used as adjunctive treatment in obese patients (obesity) whose body mass index (BMI) is over 30.

The BMI is calculated according to the following formula: BMI = body weight in kilograms / (height in meters) 2. However, the active ingredient should only be used if other appropriate weight-loss measures have not been successful. Patients who have not been able to lose weight through diet and exercise but are in dire need of medical attention should opt for a short-term treatment with amfepramone.

Because it is a central nervous anorectic, side effects are common and there is potential for abuse. In the summer of 2001, the Federal Institute for Drugs and Medical Devices (BfArM) had withdrawn its approval from ametpramone due to adverse reactions to appetite suppressants.

In contrast, the manufacturers complained successfully. Since 2004, the preparations are back on the market. However, the effectiveness for actual, long-term weight loss is controversial. Therefore, amfepramone is prescribed only in isolated cases and is basically used only for the short-term treatment of obesity.

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risks & side effects

The German BfArM and other EU drug regulatory agencies expressly point out the low medical benefit in relation to the serious side effects. Side effects included psychosis, depression, hallucinations, restlessness, sleep disorders, palpitations, high blood pressure, dizziness, and drowsiness. Amfepramone also appears to favor the development of pulmonary hypertension (pulmonary arterial hypertension).

In some patients, amfepramone may cause dangerous cardiac arrhythmias, including heart attack or cardiac arrest. With prolonged use of amfepramone can occur dependence and withdrawal of the drug withdrawal symptoms.

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What experiences and hints do you have about amfepramone??

Comments and experiences from other visitors

Kittycat commented on 29.09.2017

I forbid with the Nuvaring. Is the effect of Nuvaringes affected by Amfepramon?

Body commented on 27.12.2018

I have a height of 1.73 meters. I am 56 years old and weighed 86 kg. I’ve been trying to quit smoking for years, which I eventually did. As a result, many kilos have come to it, which I did not get away in everyday life. I had and still have a lot of stress and was incapacitated for work after a burnout because of depression. Then I returned to everyday life and even after my many sporting activities, my weight has not been significantly reduced. I was dissatisfied and looked around the internet for opportunities. I found Regenon then. I ordered Regenon from an internet online doctor and took a pill three times a day. Now I have actually lost weight and now weigh 75 kg. I’m not completely satisfied yet, but I’d like to leave it at that. The intake at the beginning was actually as described with hunger suppression and I loved it. Side effects such as headache have occurred, but then became less. Otherwise, there were no other side effects that were mentioned. I have not noticed any heart or lung problems, but I have never had any of these or similar diseases. I have been taking these tablets for almost three months now and notice that the effect of the feeling of hunger subsides. Especially in the evening I have a big appetite and really have to restrain myself. However, I am on vacation and every day at home and hardly distracted. In the cold, I can not do much outdoors. Most of the time I ride a bicycle, weather permitting. I’m going for a walk, but I’m not a jogger. Once a week I go to the sport and ride a total of about 15 to 20 km in the week so by mountain bike. And not slowly. I too am afraid of side effects and do not want to die of course. Now I will stop taking stuff and try to keep my weight in the normal way and possibly reduce a little more.

Gast commented on 14.01.2019

My partner has been taking TENUATE Retard tablets for a week and is totally aggressive and has mood swings. My question: How should I handle it??

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